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in these embodiments the antimicrobial agent s may be selected from the group that includes, but is not limited to, an aminoglycoside, such as amikacin, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, tobramycin or paromomycin; a carbacephem, such as loracarbef; a carbapenem, such as ertapenem, doripenem, imipenem cilastatin or meropenem; a cephalosporin, such as cefadroxil, cefazolin, cefalotin, cefalexin, cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefepime or ceftobiprole; a glycopeptide, such as teicoplanin or vancomycin; a macrolide, such as azithromycin, clarithromycin, dirithromycin, erythromycin, erythroped, roxithromycin, troleandomycin, telithromycin or spectinomycin; a monobactam, such as aztreonam; a penicillin, such as amoxicillin, ampicillin, azlocillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, mezlocillin, meticillin, nafcillin, oxacillin, penicillin, piperacillin or ticarcillin; a polypeptide, such as bacitracin, colistin or polymyxin b; a quinolone, such as ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin or trovafloxacin; a sulfonamide, such as mafenide, prontosil archaic , sulfacetamide, sulfamethizole, sulfanilamide archaic , sulfasalazine, sulfisoxazole, trimethoprim or trimethoprim-sulfamethoxazole cotrimoxazole tmp-smx ; a tetracycline, such as demeclocycline, doxycycline, minocycline, oxytetracycline or tetracycline; as well as chloramphenicol, clindamycin, lincomycin, fusidic acid, furazolidone, linezolid, metronidazole, mupirocin, nitrofurantoin, macrobid, platensimycin, quinupristin dalfopristin, rifampin or rifampicin.

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patients taking sulfa antibiotics, such as co-trimoxazole septra or trimethoprim women who are pregnant or breastfeeding women of child bearing potential who do not use reliable contraception patients with an infection.

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with its greater efficacy against a limited number of bacteria, co-trimoxazole remains indicated for some infections; for example, it is used as prophylaxis in patients at risk for pneumocystis jirovecii pneumonia e.

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the reversal may be due to loss of plasmids encoding resistance to chloramphenicol and other first line drugs like ampicillin, co-trimoxazole or may be due to emergence of susceptible strains.


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