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Since there is no specific antidotetreatment is primarily supportiveA patent airway must be established by use of an oropharyngeal airway or endotracheal tube orin prolonged cases of comaby tracheostomyRespiratory depression may be counteracted by artificial respiration and mechanical respiratorsHypotension and circulatory collapse may be counteracted indocin on line orders. by use of intravenous fluidsplasmaor concentrated albuminand vasopressor agents such as metaraminolphenylephrine and norepinephrineEpinephrine should not be usedIn case of severe extrapyramidal reactionsantiparkinson medication should be administeredECG and vital signs should be monitored especially for signs of Q-T prolongation or dysrhythmias and monitoring should continue until the ECG is normalSevere arrhythmias should be treated with appropriate anti-arrhythmic measures.
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported in association with antipsychotic drugssee ADVERSE REACTIONSClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental statusincluding catatonic signsand evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresisand cardiac dysrhythmiasAdditional signs may include elevated creatine phosphokinasemyoglobinuriarhabdomyolysisand acute renal failure.
Haloperidol is a psychiatric medicationantipsychotic-typethat works by helping to restore the balance of certain natural substances in the brainneurotransmitters
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