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Hepatitis is the major toxic effect of isoniazid.

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We carried out a prospective double blind placebo controlled trial of isoniazid versus placebo given with co-trimoxazole ctx either daily or three times a week in children with hiv in two centres in cape town, south africa.

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Irinotecan liposomal moderate use caution if irinotecan liposomal is coadministered with isoniazid, inh, a cyp3a4 inhibitor, due to increased risk of irinotecan-related toxicity.

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Glycaemic control may be affected by diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, chlorpromazine and isoniazid.

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aliskiren; amlodipine; hydrochlorothiazide, hctz moderate cyp3a4 inhibitors, such as isoniazid, inh, may increase the plasma level of amlodipine a cyp3a4 substrate via cyp3a4 inhibition; this effect might lead to hypotension in some individuals.

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