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Fertility of male or female rats was not affected by metformin when administered at doses up to 600 mg kg day, which is approximately 3 times the maximum recommended human daily dose based on body surface area comparisons.

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studies using single oral doses of metformin hydrochloride 500 to 1500 mg, and 850 to 2550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination.

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a randomized controlled trial is needed to clarify whether use of metformin in this subgroup would be safe and efficacious.

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nesina alogliptin , kazano alogliptin and metformin hcl , and oseni alogliptin and pioglitazone are prescription medicines used with diet and exercise to improve blood sugar glucose control in adults with type 2 diabetes.


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