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therefore, when such a patient is placed on a broad spectrum antibiotic that eliminates many of the intestinal bacteria, the bioavailability of digoxin may suddenly increase.

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after verifying proportionality assumptions, multivariate cox proportional hazards models were used to assess the impact of digoxin as a time-dependent covariate on all-cause mortality, cardiovascular mortality, and arrhythmic cardiovascular mortality while controlling for multiple covariates including demographic characteristics, comorbidities, hf, and af-related variables.

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