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Since Rocaltrolcalcitriolis believed to be the active hormone which exerts vitamin D activity in the bodyadverse effects arein generalsimilar to those encountered with excessive vitamin D intakeiehypercalcemia syndrome or calcium intoxicationdepending on the severity and duration of hypercalcemiasee WARNINGSBecause of the short biological half-life of calcitriolpharmacokinetic investigations have shown normalization of elevated serum calcium within a few days of treatment withdrawaliemuch faster than in treatment with vitamin D 3 preparations.
This medication may be available under multiple brand names and/or in several different formsAny specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed hereAs wellsome forms of this medication may not be used for all of the conditions discussed here.
Ensure that you are drinking enough fluid and do not become dehydrated while taking calcitriolYour doctor or pharmacist should be able to tell you how much fluid you need to be taking in.
General treatment of hypercalcemiagreater than 1 mg/dL above the upper limit of the normal rangeconsists of immediate discontinuation of Rocaltrolcalcitrioltherapyinstitution of a low-calcium diet and withdrawal of calcium supplementsSerum calcium levels should be determined daily until normocalcemia ensuesHypercalcemia frequently resolves in 2 to 7 daysWhen serum calcium levels have returned to within normal limitsRocaltrolcalcitrioltherapy may be reinstituted at a dose of 0.25 mcg/day less than prior therapySerum calcium levels should be obtained at least twice weekly after all dosage changes and subsequent dosage titrationIn dialysis patientspersistent or markedly elevated serum calcium levels may be corrected by dialysis against a calcium-free dialysate.
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