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In some embodiments, the serpina-1 polypeptide comprises the amino acid sequence set forth as edpqgdaaqktdtshhdqdhptfnkitpnlaefafs seq id no 4 .

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in some embodiments, the serpina-1 polypeptide and or albumin polypeptide is polymerized serpina-1 polypeptide or polymerized albumin polypeptide respectively.

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in mrcardio mice, both doxycycline treatment, which blunts mr overexpression, and canrenoate treatment, which blocks mr activity, prevented the rise in cardiac serpina-3 expression fig.

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examples of serpina-1 biomarkers are set forth herein as seq id nos 1-4.

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