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The authors concluded that the data are compatible with most models that attempt to account for chloroquine resistance and that some energy-dependent mechanism leads to loss of chloroquine from cqr cells and to its accumulation in cqs cells.

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chloroquine cq remains the mainstay of treatment for vivax malaria in most endemic countries, but drug resistance has emerged in south-east asia and is spreading 4 .

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the majority of cases of retinotoxicity have occurred in patients that have had a culmulative dose of 1000g of hydroxychloriquine plaquenil or 460g chloroquine.

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