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Imuran is available as an anti-metabolite tablet to be taken orally and each tablet has 50 mg of azathioprine.
Information about Imuran.
The mechanisms whereby azathioprine affects autoimmune diseases are not knownAzathioprine is immunosuppressivedelayed hypersensitivity and cellular cytotoxicity tests being suppressed to a greater degree than are antibody responsesIn the rat model of adjuvant arthritisazathioprine has been shown to inhibit the lymph node hyperplasiawhich precedes the onset of the signs of the diseaseBoth the immunosuppressive and therapeutic effects in animal models are dose-relatedAzathioprine is considered a slow-acting drug and effects may persist after the drug has been discontinued.
Imuranin combination with corticosteroids and/or other immunosuppressive agents and proceduresis indicated to enhance the survival of organ transplantssuch as renal transplantscardiac transplantsand hepatic transplantsand to reduce the corticosteroid requirements of renal transplant recipients.
Macrophage activation syndromeMASis a knownlife-threatening disorder that may develop in patients with autoimmune conditionsin particular with inflammatory bowel diseaseIBDand there could potentially be an increased susceptibility for developing the condition with the use of azathioprineIf MAS occursor is suspectedevaluation and treatment should be started as early as possibleand treatment with azathioprine should be discontinuedPhysicians should be attentive to symptoms of infection such as EBV and cytomegalovirusCMVas these are known triggers for MAS.
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severe diarrhoea, recurring on re-challenge, has been reported in patients treated with imuran for inflammatory bowel disease.