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Increases in HbA1c and fasting serum glucose levels have been reported with HMGCoA reductase inhibitorsincluding CRESTORBased on clinical trial data with CRESTORin some instances these increases may exceed the threshold for the diagnosis of diabetes mellitussee ADVERSE REACTIONS

Adults who cannot control their cholesterol levels by diet and exercise alone children 8 to 17 years of age with heterozygousfamilialhypercholesterolemiaan inherited condition that causes high levels of LDLchildren 7 to 17 years of age with homozygous familial hypercholesterolemiaan inherited condition that causes high levels of LDL

Patients with a known hypersensitivity to any component of this productHypersensitivity reactions including rashpruritusurticariaand angioedema have been reported with CRESTORsee ADVERSE REACTIONSPatients with active liver diseasewhich may include unexplained persistent elevations of hepatic transaminase levelssee WARNINGS AND PRECAUTIONSPregnancysee Use in Specific PopulationsLactationLimited data indicate that CRESTOR is present in human milkBecause statins have the potential for serious adverse reactions in nursing infantswomen who require CRESTOR treatment should not breastfeed their infantssee Use in Specific Populations

The chemical name for rosuvastatin calcium is bisE744-fluorophenyl6-isopropyl-2methyl(methylsulfonyl)aminopyrimidin-5-yl3R,5S3,5-dihydroxyhept-6-enoic acidcalcium salt with the following structural formula:

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