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Using the same technique, we also found an increase in hdac2 gene transcription in response to repeated fluoxetine administration; the most pronounced effect took place in the striatum table 1 , thus confirming the increase in hdac2 labeling intensity we observed immunohistochemically.
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incidence in us depression, ocd, and bulimia placebo – controlled clinical trials excluding data from extensions of trials table 6 enumerates the most common treatment-emergent adverse reactions associated with the use of fluoxetine up to 80 mg incidence of at least 2 for fluoxetine and greater than placebo in female patients ages 18 to 45 years from us placebo-controlled clinical trials in the treatment of depression, ocd, and bulimia.
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due to the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, thioridazine should not be administered with fluoxetine or within a minimum of 5 weeks after fluoxetine has been discontinued see contraindications 4 .
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