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If any of the conditions/risk factors mentioned below is presentthe benefits of the use of CPA+EE should be weighed against the possible risks for each individual woman and discussed with the woman before she decides to start using CPA+EEIn the event of aggravationexacerbation or first appearance of any of these conditions or risk factorsthe woman should contact her physicianThe physician should then decide on whether the use of CPA+EE should be discontinued.

Ginette-35 is contraindicated in patients with Hypersensitivity to the active ingredients cyproterone acetate and/or ethinyl estradiol or to any of the other components of the medicinePersonal or family history of confirmedidiopathic venous thromboembolismVTEwhere a family history refers to VTE in a sibling or parent at a relatively early agePresence or a history of venous or arterial thrombotic/thromboembolic eventse.gdeep venous thrombosispulmonary embolismmyocardial infarctionor of a cerebrovascular accidentSickle-cell anaemia Presence or history of prodromi of a thrombosise.gtransient ischaemic attackangina pectorisPresence of severe suhagraat ka video. or multiple risk factor(sfor venous or arterial thrombosis History of migraine with focal neurological symptomsDiabetes mellitus with vascular involvementPancreatitis or a history thereof if associated with severe hypertriglyceridemia.Severe hepatic disease as long as liver function values have not returned to normal.Jaundice or persistent itching during a previous pregnancyDubin-Johnson syndromeRotor syndrome History of deterioration of otosclerosis during pregnanacyPresence or history of liver tumorsbenign or malignantKnown or suspected sex steroid influenced malignanciese.gof the genital organs or the breastsUndiagnosed vaginal bleedingKnown or suspected pregnancyLactationDisorders of lipid metabolism History of herpes gestationis.

In animal studiesCPA+EElike many other steroidswhen given in very high doses and for the majority of the animal’s life-spanhas been found to cause an increase in the incidence of tumoursincluding carcinomain the liver of ratsThe relevance of this finding to humans is unknown.

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