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In primate models to assess the positive reinforcing effects of psychoactive drugs, bupropion was self-administered intravenously.

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levodopa sinemet – may increase side effects drugs that increase dopaminergic or noradrenergic activity – may increase risk of hypertension ritonavir, lopinavir, and efavirenz – ritonavir, lopinavir, and efavirenz are cyp2b6 inducers and may lower bupropion levels to subtherapeutic levels tamoxifen – tamoxifen is metabolized by cyp2d6 to its active form.

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bupropion is effective in not only relieving depression symptoms but also helps to decrease nicotine cravings.

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