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Orlistat blocks about 25 of the fat in a meal by blocking lipase.

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Patients should be asked if they are taking cyclosporinebeta carotene or vitamin E supplementslevothyroxinewarfarinantiepileptic drugsamiodaroneor antiretroviral drugs due to potential interactionssee DRUG INTERACTIONS

Never share orlistat with another personespecially someone with a history of eating disorders.

In the 4-year XENDOS studythe general pattern of adverse events was similar to that reported for the 1and 2-year studies with the total incidence of gastrointestinal-related adverse events occurring in year 1 decreasing each year over the 4-year period.

Patients should be informed of potential risks which include lowered absorption of fat-soluble vitamins and potential liver injuryincreases in urinary oxalateand cholelithiasissee WARNINGS AND PRECAUTIONSTreatment with XENICAL may result in weight loss and improvement in obesity-related risk factors due to weight losssee Clinical Studies

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a recent systematic review and meta-analysis of economic evaluations of weight loss drug treatments included 14 articles, of which 9 were on orlistat.