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The results showed taking proton pump inhibitors such as nexium was associated with a 20- to 50-percent higher risk of developing chronic kidney disease.

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Avoid administration of PPIs for longer than medically indicatedIf signs or symptoms consistent with CLE or SLE are noted in patients receiving NEXIUMdiscontinue the drug and refer the patient to the appropriate specialist for evaluationMost patients improve with discontinuation of the PPI alone in 4 to 12 weeks.

Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.

This medicine can cause diarrheawhich may be a sign of a new infectionIf you have diarrhea that is watery or bloodycall your doctor before using anti-diarrhea medicine.

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if information had been provided to consumers and the medical community about the potential link between nexium and kidney injury, many people may have avoided serious and life-threatening complications by limiting their use of this drug or choosing a different treatment alternative.