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Lomitapide moderate caution should be exercised when lomitapide is used with other medications known to have potential for hepatotoxicity, such as methotrexate.

Vancomycin moderate recent exposure to vancomycin, in the absence of overt renal impairment, may adversely affect methotrexate excretion and increase risk of toxicity.

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Pregnant psoriatic patients should not receive methotrexate.

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Alternatively, you could take paracetamol acetominophen , as this does not interfere with methotrexate.

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At high dosages, methotrexate is known to cause miscarriage and or stillbirth, especially in the first 3 months of pregnancy.

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feldene interacts with the following drugs a blood thinner such as warfarin; lithium; methotrexate;.