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Patients should be off all opioids, including opioid-containing medicines, for a minimum or 7 to 10 days before starting naltrexone hydrochloride in order to avoid precipitation of opioid withdrawal.
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Cases of hepatitis and clinically significant liver dysfunction were observed in association with REVIA exposure during the clinical development program and in the postmarketing periodTransientasymptomatic hepatic transaminase elevations were also observed in the clinical trials and postmarketing periodWhen patients presented with elevated transaminasesthere were often other potential causative or contributory etiologies identifiedincluding pre-existing alcoholic liver diseasehepatitis B and/or C infectionand concomitant usage of other potentially hepatotoxic drugsAlthough clinically significant liver dysfunction is not typically recognized as a manifestation of opioid withdrawalopioid withdrawal that is precipitated abruptly may lead to systemic sequelaeincluding acute liver injury.
In view of the lack of actual experience in the treatment of REVIA overdosepatients should be treated symptomatically in can you get flovent in canada. a closely supervised environmentPhysicians should contact a poison control center for the most up-to-date information.
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There is limited clinical experience with REVIA overdosage in humansIn one studysubjects who received 800 mg daily REVIA for up to one week showed no evidence of toxicity.
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there are only three maintenance medications that the food and drug administration fda has approved to treat recovery from alcohol abuse disulfiram antabuse , naltrexone vivitrol , and acamprosate campral .