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Das trinken von alkohol kann das risiko von nebenwirkungen durch quibron-t erh hen.
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Ask your healthcare professional how you should dispose of any medicine you do not use.
Using this medicine with any of the following medicines may cause an increased risk of certain side effectsbut using both drugs may be the best treatment for youIf both medicines are prescribed togetheryour doctor may change the dose or how often you use one or both of the medicines.
Elderly patients are at significantly greater risk of experiencing serious toxicity from theophylline than younger patients due to pharmacokinetic and pharmacodynamic changes associated with agingTheophylline clearance is reduced in patients greater than 60 years of ageresulting in increased serum theophylline concentrations in response to a given theophylline doseProtein binding may be decreased in the elderly resulting in a larger proportion of the total serum theophylline concentration in the pharmacologically active unbound formElderly patients also appear to be more sensitive to the toxic effects of theophylline after chronic overdosage than younger patientsFor these reasonsthe maximum daily dose of theophylline in patients greater than 60 years of age ordinarily should not exceed 400 mg/day unless the patient continues to be symptomatic and the peak steady state serum theophylline concentration is 300 mg/day in adults and12 mg/kg/day in children beyond1 year of ageDuring the initiation of theophylline therapycaffeine-like adverse effects may transiently alter patient behaviorespecially in school age childrenbut this response rarely persistsInitiation of theophylline therapy at a low dose with subsequent slow titration to a predetermined age-related maximum dose will significantly reduce the frequency of these transient adverse effectssee DOSAGE AND ADMINISTRATIONTable VIn a small percentage of patientsTable IVManifestations of theophylline toxicity
Other manifestations of theophylline toxicity include increases in serum calciumcreatine kinasemyoglobin and leukocyte countdecreases in serum phosphate and magnesiumacute myocardial infarctionand urinary retention in men with obstructive uropathy.
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