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Orthostatic hypotension can occur with Clozaril treatment and there have been reports of tachycardiawhich may be sustainedPatients aged 60 years and olderparticularly those with compromised cardiovascular functionmay be more susceptible to these effects.
No paediatric studies have been performedThe safety and efficacy of Clozaril in children and adolescents under the age of 16 years have not yet been establishedIt should not be used in this group until further data become available.
A very serious allergic reaction to this drug is unlikelybut seek immediate medical attention if it occursSymptoms of a serious allergic reaction may includerashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
The dosage must be adjusted individuallyFor each patient the lowest effective dose should be usedFor doses not realisable/practicable with one strengthother strengths of this medicinal product are availableCautious titration and a divided dosage schedule are necessary to minimise the risks of hypotensionseizure and sedation.
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