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Patients who were responders on paroxetine during the 3 month double-blind phase and a 6 month extension on open-label paroxetine 20 to 60 mg day were randomized to either paroxetine or placebo in a 6 month double-blind relapse prevention phase.

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although in controlled studies immediate-release paroxetine hydrochloride has not been shown to impair psychomotor performance, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy with paxil cr does not affect their ability to engage in such activities.


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