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The possible need for combination therapy with gastro-protective agentse.gmisoprostol or proton pump inhibitorsshould be carefully consideredsee section 4.2

NSAIDs cause an increased risk of serious gastrointestinalGIadverse events including bleedingulcerationand perforation of the stomach or intestineswhich can be fatalThese events can occur at any time during use and without warning symptomsElderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI eventssee WARNINGS AND PRECAUTIONS

NSAIDsincluding piroxicamcan cause serious gastrointestinal events including bleedingulcerationand perforation of the stomachsmall intestine or large intestinewhich can be fatalThese serious adverse events can occur at any timewith or without warning symptomsin patients treated with NSAIDs.

Feldene is indicated for symptomatic relief of osteoarthritisrheumatoid arthritis or ankylosing spondylitis.

PregnancyAlthough no teratogenic effects were seen in animal testingthe safety of Feldene during pregnancy or during lactation has not yet been establishedFeldene inhibits prostaglandin synthesis and release through a reversible inhibition of the cyclo-oxygenase enzymeThis effectas with other non-steroidal anti-inflammatory drugshas been associated with an increased incidence of dystocia and delayed parturition in pregnant animals when drug administration was continued in late pregnancyIn view of the known effects buy cheap abortion pills online. of NSAIDs on the foetal cardiovascular systemrisk of closure of the ductus arteriosususe in the last trimester of pregnancy is contraindicatedThe onset of labour may be delayed and the duration increased with an increased bleeding tendency in both mother and childsee section 4.3

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