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Summary, this study did not demonstrate significant changes in insulin sensitivity in healthy subjects after 3 wk of treatment with olanzapine or risperidone.
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while d 2 and 5-ht 2a receptors play a critical role in the therapeutic effects of olanzapine 15 , 16 , evidence indicates that the h 1 , 5-ht 2c , and m 3 receptors are involved in antipsychotic-induced metabolic side-effects 8 , 9 , 17 24 .
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in the trial by harrigan and colleagues, both risperidone and olanzapine had clinically insignificant increases in qtc 3.
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although the evidence base is limited because most studies have few patients, one study compared valproate depakote with olanzapine zyprexa , valproate depakote with risperidone risperdal , olanzapine zyprexa with placebo, and risperidone risperdal with placebo and concluded that the valproate depakote groups improved significantly more rapidly over the first 2 weeks of treatment than the antipsychotic group alone.
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the ruling gave canada s pharmaceutical industry the green light to begin producing and distributing olanzapine; the generic equivalent of eli lilly s brand name zyprexa.
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