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AffiliationCentre for Population Health SciencesMedical SchoolUniversity of EdinburghEdinburghUnited Kingdom.

Forest plot of meta-analyzed results for the effect per minor allele of rs28929474PI Zon FEV1 in ever-smokersadjusted for sexageheight and population stratification factorsStudies based on population isolates with a high degree of cryptic relatedness are presented separatelyEffect estimates of meta-analyses are shown with green diamondsI 2 is a measure of the heterogeneity between studiesRandom effect meta-analyses are included if I 20.5Study weightsblue squarescorrespond to the fixed effect meta-analyses.

SAPALDIA study design for the determination of AAT associated genetic variantsa consisting of subjects with abnormally low AAT levels independent of PI S or Z allelessee Materials and Methods

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