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Concomitant strong cyp1a2 inhibitors eg, fluvoxamine, ciprofloxacin, enoxacin reduce clozaril dose to one-third.

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clozaril is used for managing schizophrenia in patients who do not respond to other medicines.

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the first of the atypical antipsychotics, clozapine clozaril, fazaclo , is the only agent that has been shown to be effective where other antipsychotics have failed.

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however, it has been proposed that the therapeutic efficacy of clozaril in schizophrenia is mediated through antagonism of the dopamine type 2 and the serotonin type 2a 5-ht 2a receptors.

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