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These symptoms occurred within 3-5 days of beginning tamoxifen and cleared within 2-5 days after stopping therapy.

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in patients treated with nolvadex tamoxifen citrate for metastatic breast cancer, the most frequent adverse reaction to nolvadex tamoxifen citrate is hot flashes.

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in women with breast cancer who are at high risk of developing a second breast cancer, treatment with about 5 years of tamoxifen reduced the annual incidence rate of a second breast cancer by approximately 50 .

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in the nsabp p-1 trial, among participants randomized to tamoxifen there was a statistically significant increase in the incidence of endometrial cancer 33 cases of invasive endometrial cancer, compared to 14 cases among participants randomized to placebo rr 2.


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