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These results suggest that i neuronal synchronization involved in epileptiform activity can be dissociated from synaptic excitability; ii nonsynaptic mechanisms, possibly associated with furosemide-sensitive cell volume regulation, may be critical for synchronization of neuronal activity; and iii agents that affect extracellular volume may have clinical utility as antiepileptic drugs.

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these drugs include diuretics, for example, hydrochlorothiazide hydrodiuril, ezide, hydro-par, microzide, and many combinations with other drugs , furosemide lasix , corticosteroids such as prednisone and methylprednisolone medrol , phenytoin dilantin ,niacin, and sympathomimetics such as pseudoephedrine sudafed .

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In liver disease, small doses of all diuretics are usually may occur with potassium-losing diuretics eg, hydro- indicated because diuretic-induced electrolyte imbal- chlorothiazide, furosemide .

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