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In bioequivalence studies of actoplus met 15 mg 500 mg and 15 mg 850 mg, the area under the curve auc and maximum concentration cmax of both the pioglitazone and the metformin component following a single dose of the combination tablet were bioequivalent to actos 15 mg concomitantly administered with glucophage 500 mg or 850 mg respectively tablets under fasted conditions in healthy subjects.
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